Absolutely. River tables are increasing in popularity. System Three has developed a two-part epoxy casting resin called Rivercast™ which will work well for pouring the "river" in these kinds of tables. This product, new for 2018, passed field tests with flying colors. Product description and usage instructions, complete with tips and tricks for coloring, are in the downloadable document below.
A demonstration video is in the works and will be posted here as soon as it's ready.